業績紹介

2024年

  1. Urushitani M, Nakamura R; Hypermetabolism in ALS: Step Ahead Toward Global Consensus: Editorial.
    Neurology, 2024, 102, e209179.

2023年

  1. Urushitani M, Warita H, Atsuta N, Izumi Y, Kano O, Shimizu T, Nakayama Y, Narita Y, Nodera H, Fujita T, Mizoguchi K, Morita M, Aoki M; the ALS Clinical Practice Guideline Development Committee, Japanese Society of Neurology. The clinical practice guideline for the management of amyotrophic lateral sclerosis in Japan – update 2023. Clinical Neurology (Rinsho Shinkeigaku), 2023, in press
  2. Nakamura R, Kurihara M, Kobashi S, Tamaki Y, Ogawa N, Kitamura A, Yamakawa I, Bamba S, Terashima T, Urushitani M. Ideal Body Weight-Based Determination of Minimum Oral Calories Beneficial to Function and Survival in ALS. Front Neurol, 2023, in press
  3. Hirayama T, Shibukawa, Morioka H, Hozumi M, Tsuda H, Atsuta N, Izumi Y, Nakayama Y, Shimizu T, Inoue H, Urushitani M, Yamanaka K, Aoki M, Ebihara S, Takeda A, Kano A.The urgent need to advance disaster preparedness for patients with amyotrophic lateral sclerosis and their families. J Clin Neurosci 2023, 116:87-92. doi: 10.1016/j.jocn.2023.08.002.
  4. Yabata H, Riku Y, Miyahara H, Akagi A, Sone J, Urushitani M, Yoshida M, Iwasaki Y. Nuclear Expression of TDP-43 is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis.Int J Mol Sci, 2023; 24(15):12176. https://doi.org/10.3390/ijms241512176
  5. 音羽祐兵、山川 勇、真田 充、漆谷 真. IgG4 上昇と膜性腎症を伴った Contactin-1 抗体関連ニューロパチーの 1 例. Peripheral Nerve 末梢神経．34, 1, 2023、 印刷中
  6. Wada H, Hikiami R, Kusui M, Minamiyama S, Asada-Utsugi M, Shodai A, Muramatsu SI, Morimura T, Urushitani M. In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD. Neurosci Res, 2023 Aug;193:41-51. doi: 10.1016/j.neures.2023.02.006.
  7. Minamiyama S, Sakai M, Yamaguchi Y, Kusui M, Wada H, Hikiami R, Tamaki Y, Asada-Utsugi M, Shodai A, Makino A, Fujiwara N, Ayaki T, Maki T, Warita H, Aoki M, Tomonaga K, Takahashi R, Urushitani M. Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model. Mol Ther Methods Clin Dev, 2023;28:312-329. doi: 10.1016/j.omtm.2023.01.008.
  8. 中村竜太郎, 北村彰浩, 塚本剛士, 小橋修平, 小川暢弘, 山川　勇, 真田　充, 漆谷　真. 筋萎縮性側索硬化症における必要カロリー量の指標について. 日本神経摂食嚥下･栄養学会誌 2023, 印刷中
  9. 杉山誠治, 北村彰浩, 金子隼也, 山川 勇, 真田 充, 漆谷 真．多発血管狭窄や椎骨動脈瘤等の多彩な血管病変を呈したNeuropsychiatric systemic lupus erythematosusの1例. 臨床神経 2023 (印刷中)
  10. Tamaki Y, Ross JP, Alipour P, Catoire H, Rochefort D, Urushitani M, Takahashi R, Sonnen JA, Stifani S, Dion PA, Rouleau G. Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids. PLoS Genet. 2023 Feb 6;19(2):e1010606. doi: 10.1371/journal.pgen.1010606.

2022年

  1. Yamakawa I, Yamada A, Sonoda Y, Wakita K, Nishioka T, Harada Y, Ogawa N, Kitamura A, Sanada M, Tani T, Imai S, Urushitani M. Occupational therapy using a robotic-assisted glove ameliorates finger dexterity and modulates functional connectivity in amyotrophic lateral sclerosis. J Clin Neurosci. 2022 Nov 18:S0967-5868(22)00446-5. doi: 10.1016/j.jocn.2022.11.004. Epub ahead of print. PMID: 36411175.
  2. Tamaki Y, Urushitani M. Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD. Int J Mol Sci 2022, 23, 12508. https://doi.org/10.3390/ijms232012508
  3. Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu S, Ueki T, Takahashi R, Urushitani M. Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induced mitochondrial dysfunction and cytosolic aggregates. Sci Rep 12, 16030 (2022). https://doi.org/10.1038/s41598-022-20405-2
  4. Takekoshi A, Kimura A, Yoshikura N, Yamakawa I, Urushitani M, Nakamura K, Yoshida K, Shimohata T. Clinical features and neuroimaging findings of neuropil antibody-positive sporadic adult-onset cerebellar ataxia of unknown etiology. Cerebellum. 2022 Sep 3. doi: 10.1007/s12311-022-01468-3.
  5. Sawamura M, Imamura K, Hikawa R, Enami T, Nagahashi A, Yamakado H, Ichijyo H, Fujisawa T, Yamashita H, Minamiyama S, Kaido M, Wada H, Urushitani M, Inoue H, Egawa N, Takahashi R. Cellular analysis of SOD1 protein-aggregation propensity and toxicity ? A case of ALS with slow progression harboring homozygous SOD1-D92G mutation. Sci Rep 2022 Jul 25;12(1):12636. doi: 10.1038/s41598-022-16871-3.
  6. Ishiyama H, Tanaka T, Saito S, Koyama T, KitamuraA, Inoue M, Fukushima N, Morita Y, Koga M, Toyoda K, Kuriyama N, Urushitani M, Ihara M. Plasma Mid-regional pro-adrenomedullin: A Biomarker of the Ischemic Penumbra in Hyperacute Stroke. Brain Pathol. 2022 Aug 2:e13110. doi: 10.1111/bpa.13110.
  7. Tram HTH, Tanaka-Mizuno S, Takashima N, Kawser K, Arima H, Kadota A, Fujii T, Shitara S, Kitamura A, Miyamatsu N, Kita Y, Urushitani M, Nakagawa Y, Miura K, Nozaki K. Control of diabetes mellitus and long-term prognosis in stroke patients: The Shiga Stroke and Heart Attack Registry. Cerebrovasc Dis 2022 Aug 3:1-8. doi: 10.1159/000525648. Epub ahead of print. PMID: 35921810.
  8. 山中雄翔, 米津 亮, 久郷真人, 澤野翔一朗, 宮垣茉梨奈, 田村亮太, 山川 勇, 今井晋二, 漆谷  真. 脊髄小脳変性症患者に対する短期集中リハビリテーション前後のバランス機能の変化―Mini–Balance Evaluation Systems Test の有用性の検討 ―神経治療 39：94–97，2022
  9. Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S, Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K, Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K, Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Neurol. 2022 May 9. doi: 10.1001/jamaneurol.2022.0901. Epub ahead of print. PMID: 35532908.
  10. Asada-Utsugi M, Uemura K, Ayaki T, Uemura T-M, Minamiyama S, Hikiami R, Morimura T, Shodai A, Takahashi R, Ueki T, Kinoshita A, Urushitani M. Failure of DNA Double-Strand Break Repair by Tau Mediates Alzheimer’s disease Pathology in vitro. Commun Biol 2022, Vol. 5, 358, DOI: 10.1038/s42003-022-03312-0
  11. Nakamura R, Kurihara M, Ogawa N, Kitamura A, Yamakawa I, Bamba S, Sanada M, Sasaki M, Urushitani M. Investigation of the prognostic predictive value of serum lipid profiles in amyotrophic lateral sclerosis: roles of sex and hypermetabolism. Sci Rep 12: 1826, 2022, DOI: 10.1016/j.pneurobio.2022.102229
  12. Kobashi S, Terashima T, Katagi M, Urushitani M, Kojima H. Bone marrow-derived inducible microglia-like cells ameliorate motor function and survival in a mouse model of amyotrophic lateral sclerosis. Cytotherapy. 2022, Apr 4:S1465-3249(22)00047-0. doi: 10.1016/j.jcyt.2022.02.001.
  13. Shitara S, Tanaka-Mizuno S, Takashima N, Fujii T, Arima H, Kita Y, Tsuji A, Kitamura A, Urushitani M, Miura K, Nozaki K on behalf of the Shiga Stroke and Heart Attack Registry Group. Population-based incidence rates of subarachnoid hemorrhage in Japan: The Shiga Stroke and Heart Attack Registry. J Stroke. 2022;24(2):292-295. https://doi.org/10.5853/jos.2022.00087

2021年

  1. Otowa Y, Yamakawa I, Ogawa N, Kitamura A, Kim H, Sanada M, Urushitani M. Amoebic encephalitis mimicking acute disseminated encephalomyelitis. Pract Neurol 2021;0:1–2. doi:10.1136/practneurol-2021-002931.
  2. Asada-Utsugi M, Uemura K, Kubota M, Noda Y, Tashiro Y, Uemura M, Yamakado H, Urushitani M, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A. Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks. Mol Brain. 2021 Jan 25;14(1):23. 
  3. Sonoda Y, Yamanaka Y, Sawano S, Komada R, Kugo M, Kitamura A, Ogawa N, Yamakawa I, Kim H, Sanada M, Imai S, Urushitani M. Amelioration of motor and non-motor symptoms in cortical cerebellar atrophy and multiple system atrophy-cerebellar type by inpatient rehabilitation: a retrospective study. Int J Rehabil Res, 2021. DOI: 10.1097/MRR.0000000000000455
  4. Sonoda Y, Yoshida N, Kawami K, Kitamura A, Ogawa N, Yamakawa I, Kim H, Sanada M, Urushitani M. Short-term effect of intensive speech therapy on dysarthria in patients with sporadic spinocerebellar degeneration. J Speech Lang Hear Res. 2021 Mar 17;64(3):725-733.
  5. Nakata K, Namiki M, Nishida H, Sakai H, Yamato O, Urushitani M, Maeda S, Kamishina H. Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1 protein in canine degenerative myelopathy. Res Vet Sci. 2021 Mar;135:479-485.
  6. 岡本直己, 小川暢弘, 北村彰浩, 山川　勇, 金　一暁, 漆谷　真. 水痘・帯状疱疹ウイルス感染によるブドウ膜炎を契機に神経ベーチェット病を発症したと考えられた一例. 臨床神経 2021 年 （印刷中）
  7. Fujii T, Arima H, Takashima N, Yoshikuni Kita Y, Miyamatsu N, Tanaka-Mizuno S, Shitara S, Urushitani M, Miura K, Nozaki K. Seasonal variation in incidence of stroke in a general population of 1.4 million Japanese: the Shiga Stroke Registry. Cerebrovascular Diseases 2021  Aug 27:1-7. doi: 10.1159/000518370.
  8. Aizawa H, Kato H, Oba K, Kawahara T, Yoshihiko Okubo Y, Saito T, Naito M, Urushitani M, Tamaoka A, Nakamagoe K, Ishii K, Kanda T, Katsuno M, Atsuta, Maeda Y, Nagai M, Nishiyama K, Ishiura H, Toda T, Kawata A, Abe K, Yabe I, Takahashi-Iwata I, Sasaki H, Warita H, Aoki M, Sobue G, Mizusawa H, Matsuyama Y, Haga T, Kwak S. Randomized phase 2 study of perampanel for sporadic amyotrophic lateral sclerosis. J Neurol 2021, Jun 30. doi: 10.1007/s00415-021-10670-y.
  9. Tanaka N, Kimura S, Kamatari Y, Nakata K, Kobatake Y, Inden M, Yamato O, Urushitani M, Maeda S, Kamishina H. In vitro evidence of propagation of superoxide dismutase-1 protein aggregation in canine degenerative myelopathy. Vet J 2021, Jun 21;274:105710. doi: 10.1016/j.tvjl.2021.105710.
  10. Kurihara M, Bamba S, Yasuhara S, Itoh A, Nagao T, Nakanishi N, Nakamura R, Ogawa N, Kitamura A,  Yamakawa I, Kim H, Sanada M, Urushitani M, Sasaki M. Factors affecting energy metabolism and prognosis in patients with amyotrophic lateral sclerosis. Ann Nutr Metab, 2021, doi: https://doi.org/10.1159/000518908
  11. Nakamura R, Kurihara M, Ogawa N, Kitamura A, Yamakawa I, Bamba S, Sanada M, Sasaki M, Urushitani M. Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis. Sci Rep 2021 Sep 9;11(1):17943. doi: 10.1038/s41598-021-97196-5.

2020年

  1. Terashima T, Kobashi S, Watanabe Y, Nakanishi M, Honda N, Katagi M, Ohashi N, Kojima H. Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice. iScience. 2020 Nov 4;23(11):101764.
  2. Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson’s disease and dementia with Lewy bodies. J Neurol Sci. 2020 Aug 15;415:116928.
  3. Ayaki T, Murata K, Kanazawa N, Uruha A, Ohmura K, Sugie K, Kasagi S, Li F, Megumi Mori M, Nakajima R, Sasai T, Nishino I, Ueno S, Urushitani M, Furukawa F, Ito H, Takahashi R. Myositis with sarcoplasmic inclusions in Nakajo-Nishimura syndrome: a genetic inflammatory myopathy. Neuropathol Appl Neurobiol. 2020 Oct;46(6):579-587.
  4. Shimizu J, Tabata T, Tsujita Y, Yamane T, Yamamoto Y, Tsukamoto T, Ogawa N, Kim H, Urushitani M, Eguchi Y. Propofol infusion syndrome complicated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: a case report. Acute Med Surg. 2020;7:e473
  5. 塚本 剛士，梶川 駿介，人見 健文，舟木 健史，漆谷 真，高橋 良輔，池田 昭夫．急性外傷性脳損傷後に時定数2 秒の頭皮上脳波で皮質拡散興奮 (Cortical spreading depolarizations; CSD) が記録された一例. 臨床神経 2020 年 60 巻 7 号 p. 473-478 
  6. Nakamura R, Kitamura A, Tsukamoto T, Ogawa N, Yamakawa I, Kim H, Sanada M, Urushitani M. A case of spinal muscular atrophy type 3 showing a specific pattern of selective vulnerability on muscle ultrasound: a case report. Int Med 2020, in press.
  7. Takashima N, Arima H, Kita Y, Fujii T, Tanaka-Mizuno S, Shitara S, Kitamura A, Sugimoto Y, Urushitani M, Miura K, Nozaki K. Long-Term Survival after Stroke in 1.4 Million Japanese Population: Shiga Stroke and Heart Attack Registry. J Stroke. 2020 in press.
  8. Nakamura R, Kitamura A, Tsukamoto T, Tamura R, Ogawa N, Yamakawa I, Kim H, Kawai H, Sanada M, Urushitani M. The effect of intravenous methylprednisolone to recurrent exacerbations in hematologic malignancies-associated progressive multifocal leukoencephalopathy (PML). Int Med 2020, in press.
  9. Kobashi S, Terashima T, Katagi M, Nakae Y, Okano J, Suzuki Y, Urushitani M, Kojima H. Transplantation of M2-deviated microglia promotes recovery of motor function after spinal cord injury in mice. Mol Ther 2020, 28:254-265
  10. Tamura R, Ohara N, Murakami Y, Imamura H, Sakai N, Kohara N. Acute Internal Carotid Artery Occlusion Long after Carotid Revascularization by Vein Graft. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105391. doi: 10.1016/j.jstrokecerebrovasdis.2020.105391.

2019年

  1. Minamiyama S, Ueda S, Nakashima R, Yamakado H, Sakato Y, Yamashita H, Sawamoto N, Fujimoto Ry, Nishino I, Urushitani M, Mimori T, Takahashi R. Thigh muscle MRI findings in myopathy associated with anti-mitochondrial antibody. Muscle Nerve 2019 DOI:10.1002/mus.26731
  2. 清水　芳樹, 北村　彰浩, 塚本　剛士, 金　一暁, 川合　寛道, 漆谷　真. Cushing病とKlinefelter症候群の合併により亜急性に進行する両下肢近位筋筋力低下を呈した1例. 臨床神経，59：253－257，2019
  3. Zong C, Hasegawa R,Urushitani M, Zhang L, Nagashima D, Sakurai T, Ichihara S, Ohsako S, Ichihara G. Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro. Arch Toxicol. 2019, 93(7):2007-2019.
  4. Yamaguchi Y, Li F, Tsujimura A, Kamada M, Ito H, Maki T, Sawamoto N, Urushitani M, Takahashi R. Phosphorylated NF-kB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy. Neurosci Lett 2019, 704: 229-235.
  5. Hishizawa M, Yamashita H, Akizuki M, Urushitani M, Takahashi R. TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls. Neurochem Int. 2019, 124, 41-45

2018年

  1. Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M, Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda M, Ikeda K, Nagai M, Komai K, Kojima Y, Kuzume D, Isose S, Shimohama S, Abe K, Ito H, Noda K, Ishihara T, Morita M, Shimohata T, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R, JETALS Collabolators. A Prospective, Multicenter, Randomized Phase III Study to Evaluate the Efficacy and Safety of high dose Methylcobalamin for Amyotrophic Lateral Sclerosis (ALS): Protocol of Japan Early-stage Trial of high dose methylcobalamin for ALS. JMIR Research Protocols. 2018, 7:e12046. 
  2. Ogawa-N, Terashima-T, Oka-K, Chan-L, Kojima-H. Gene therapy for neuropathic pain using dorsal root ganglion–targeted helper-dependent adenoviral vectors with GAD67 expression. Pain Rep. 2018 Oct 15;3(6):e695.
  3. Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Sci Rep, 2018, 8, 6030
  4. Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R. Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Int Med 2018, doi: 10.2169/internalmedicine.0285-17. 
  5. Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach T, Iwai K, Dawson V, Dawson T, Takahashi R. Pathological endogenous α-Synuclein accumulation in oligodendrocyte precursor cells potentially induces inclusions in multiple system atrophy. Stem Cell Rep 2018 Feb 13;10(2):356-365.

2017年

  1. Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R. Multiple proteinopathies in familial als cases with optineurin mutation. J Neuropathol Exp Neurol 2017, doi: 10.1093/jnen/nlx109
  2. Hikiami R, Yamashita H, Koita N, Jingami N, Sawamoto N, Furukawa K, Kawai H, Terashima T, Oka N, Hashiguchi A, Takashima H, Urushitani M, and Takahashi R. Charcot-Marie-Tooth disease type 2A with an autosomal recessive inheritance; the first report of an adult-onset disease. J Hum Genet 2017, doi: 10.1038/s10038-017-0353-3.
  3. Carandang A, Takamatsu N, Nodera H, Mori A, Mimura N, Okada N, Kinoshita H, Kuzuya A, Urushitani M, Takahashi R, Izumi Y, Kaji R. Velocity of intraneural blood flow is increased in inflammatory neuropathies: sonographic observation. J Neurol Neurosurg Psychiatr 2017, 8(5):455-457.

2016年

  1. Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 2016, 628:207-212.
  2. Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T,. Yamashita H, Ito H, Takahashi R, Urushitani M. CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. Sci Rep, 2016, 6: 19118;
  3. Yanagihashi M, Kano O, Terashima T, Kawase Y, Hanashiro S, Sawada M, Ishikawa Y, Shiraga N, Ikeda K, Iwasaki Y. Late-onset spinal form xanthomatosis without brain lesion: a case report. BMC Neurol. 2016 Feb 9;16(1):21.
  4. Maeda K, Kawai H, Sanada M, Terashima T, Ogawa N, Idehara R, Makiishi T, Yasuda H, Sato SI, Hoshi KI, Yahikozawa H, Nishi K, Itoh Y, Ogasawara K, Tomita K, Indo HP, Majima HJ. Clinical Phenotype and Segregation of Mitochondrial 3243A>G Mutation in 2 Pairs of Monozygotic Twins. JAMA Neurol. 2016 Jun 20.
  5. Kobatake Y, Sakai H, Tsukui T, Yamato O, Kohyama M, Sasaki J, Kato S, Urushitani M, Maeda S, Kamishina H. Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy. J Neurol Sci 2016, in press. DOI: http://dx.doi.org/10.1016/j.jns.2016.10.034
  6. Kim H Oi J, Yamakawa I, Kawai H. String of pearls around the brainstem. A case of neurosarcoidosis. Neurology 2016, 87: 2602.

2015年

  1. Kitamura A, Saito S, b, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalariad RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. J Cereb Blood Flow Metab, 2015 in press
  2. Nakamae S, Kobatake Y, Suzuki R., Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, and Kamishina H. Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy. Neuroscience 2015 303, 229-40
  3. Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T. A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice – Relevance to the pathogenesis of ALS. Hum Mol Genet. 2015. 15: 3427-3439.
  4. Urabe H, Terashima T, Lin F, Kojima H, Chan L. Bone marrow-derived TNF-α causes diabetic neuropathy in mice. Diabetologia, 2015, 58: 402.
  5. Urabe H, Terashima T, Kojima H, Chan L. Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy. Am J Physiol Endocrinol Metab. 2015

2014年

  1. Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathologica Comm. 2014, 2, 172.
  2. Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci 2014, 127, 5204–5217
  3. Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K. Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine. Exp Biol Med 2014; 239: 489–501
  4. Oono M, Okado-Matsumoto A, Shodai A, Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M. Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. J Neurochem 2014, 128 403-418
  5. Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K. A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. Am J Hum Genet. 2014 Sep 4;95(3):294-300.
  6. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One,2014, 9: e92073.
  7. Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H. Stem Cell Factor-Activated Bone Marrow Ameliorates Amyotrophic Lateral Sclerosis by Promoting Protective Microglial Migration. J. Neurosci. Res., 2014, 92: 856.
  8. Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS letters., 2014, 588: 1080.

2013年

  1. Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M. Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43). J Biol Chem 2013, 288, 21, 14886-14905.
  2. Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat. Commun., 2013, 4:1526.

2012年

  1. Shodai A,, Ido A, Fujiwara N, Ayaki T, Morimura T, Oono M, Uchida T, Takahashi R, Ito H, Urushitani M. Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLoS ONE 2012, 2012, 7, e52776
  2. Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R. Motor Neuron-specific Disruption of Proteasomes, but not Autophagy, Replicates Amyotrophic Lateral Sclerosis. J Biol Chem, 2012, 287, 42984-4299 (YT and MU are co-first authors)
  3. Terashima T, Kojima H, Chan L. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB J., 2012, 26 (1) : 295-308.
  4. Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y. Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve. PLoS One., 2012, 7 (9): e44592.

2011年

  1. Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto A, Takahashi R, Ito H. An autopsy case of SOD1-related ALS with TDP-43 positive inclusions. Neurology, 2011, 77, 1995-1997
  2. Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R. Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model. PLoS ONE 2011, 6, e20427
  3. Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I. In vivo detection of amyloid β deposition using (19)F magnetic resonance imaging with a (19)F-containing curcumin derivative in a mouse model of Alzheimer’s disease. Neuroscience 2011,16, 184:120-127
  4. Chan L, Terashima T, Urabe H, Lin F, Kojima H. Pathogenesis of diabetic neuropathy: bad to the bone. Ann. NY. Acad. Sci., 2011, 1240 (1) : 70-76.
  5. Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H. Inactivation of TNF-α Ameliorates Diabetic Neuropathy in Mice. Am. J. Physiol. Endocrinol. Metab., 2011, 301 (5) : E844-852.

2010以前 (抜粋)

  1. Kawai H, Nakajima A. Images in clinical medicine. Red puffy ears. N Engl J Med. 2010 Mar 11;362(10):928.
  2. Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J. Clin. Invest., 2009, 119 (7) : 2100-2112.
  3. Urushitani M, Ezzi SA, Matsuo A, Tooyama I, Julien JP. The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS. FASEB J 2008, 22: 2476-2487.
  4. Urushitani M, Abou Ezzi S, Julien JP. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of ALS. Proc Natl Acad Sci U S A 2007, 104, 2495-2500
  5. Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien JP. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 2006, 9:108-118
  6. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc. Natl. Acad. Sci. U.S.A., 2005, 102: 12525-12530.
  7. Urushitani M, Shimohama S, Kihara T, Sawada H, Akaike A, Ibi M, Inoue R, Kitamura Y, Taniguchi T, Kimura J. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Ann Neurol 1998 44:796-807
  8. Urushitani M, Udaka F, Kameyama M. Miller Fisher-Guillain-Barre overlap syndrome with enhancing lesions in the spinocerebellar tracts. J Neurol Neurosurg Psychiatry 1995, 58:241-3

著書・総説

  1. 山川　勇. ALSにおける手指巧緻性障害に対するロボットリハビリテーション. 特集「筋萎縮性側索硬化症（ALS)への多彩な連携とリハビリテーション医療」. Journal of Clinical Rehabilitation. 33, 122-127, 2024
  2. 北村彰浩、漆谷　真．認知症における治療法の進歩．特集「中神経系の画像診断最前線」 ＩＮＮＥＲＶＩＳＩＯＮ 2024, 39, 47-50 インナービジョン
  3. 田村亮太、漆谷真. 筋萎縮性側索硬化症（ALS）病態における慢性炎症. 脳神経内科 2023, 99, 835-841, 科学評論社.
  4. 引網亮太、漆谷　真．異常蛋白質（TDP-43、C9orf72）と病態．脳神経内科．97巻2号, 108, 科学評論社, 2022
  5. 漆谷　真.　 筋萎縮性側索硬化症（ALS）に対する遺伝子治療.　特集：神経疾患における遺伝医療の進歩. 日本内科学会雑誌 第111巻第8号, 1527, 2022
  6. 漆谷　真. 筋萎縮性側索硬化症の先制治療を踏まえた診断進化と新たな病態理解. 脳神経内科レビュー2022-’23. 総合医学社. 東京 p170
  7. 漆谷　真．ALSに対する抗体療法開発の現状．実験医学 39, 186, 2021
  8. 和田英貴、漆谷　真．ALSにおける免疫治療．難病と在宅ケア．2021 印刷中  
  9. 漆谷　真．筋萎縮性側索硬化症．今日の治療指針2020. 医学書院．東京　p.981 
  10. 漆谷　真. 筋萎縮性側索硬化症. 今日の診断指針 第8版. 2020. 医学書院. 東京　p.644. 
  11. 真田　充、松井　真、漆谷　真. 筋萎縮性側索硬化症（ALS）と慢性炎症. Bio Clinica 9 (2), 2020
  12. 小川暢弘、北村彰浩、山川　勇、金　一暁、真田　充、漆谷　真. 急性期脳梗塞の治療の進歩．画像診断 40.(14), 1405-1416, 2020 
  13. 真田　充. 有痛性糖尿病性神経障害の病態と対策. 特集「糖尿病性神経障害の病態解明と治療戦略」　月刊糖尿病 12, 50-55, 2020 
  14. 漆谷　真．筋萎縮性側索硬化症. 特集　難病研究の進歩．生体の科学．71（ 5 ）：2─4，2020 
  15. 引網亮太, 南山素三雄, 漆谷　真．筋萎縮性側索硬化症 – プロテイノパチーの観点から．医学のあゆみ. 273(1): 44-49, 2020 
  16. 漆谷　真．神経難病治療のニューホライズン「神経難病の治療開発update」BIO Clinica, 35, 4-5, 2020 
  17. 漆谷　真．筋萎縮性側索硬化症に対する創薬開発の現状と展望「神経難病をクスリで治す」BRAIN and NERVE. 71 (1) 13-23, 2019
  18. 漆谷 真, 玉木 良高, 引網 亮太, 南山 素三雄. ALSにおける免疫療法開発の現状と展望. 特集「ALS2019」BRAIN and NERVE. 71 (11): 1289-1301, 2019
  19. 玉木 良高, 漆谷 真. 運動ニューロン疾患の抗体を用いた治療開発の展望. 脳神経内科. 90 (2): p137-145, 2019. 
  20. 漆谷　真. VHL (von Hippel-Lindau protein). 「脳内環境辞典」高橋良輔、山中宏二、樋口真人、漆谷　真 編. メディカルドゥ社, 2017, 114-145
  21. 玉木良高、漆谷　真. レドックスUPDATE「小胞体ストレスと神経変性疾患」. 淀井淳司・平家俊男監修 医歯薬出版株式会社2015, 213-219