滋賀医科大学 内科学講座 神経内科は、脳神経を診る内科として神経内科学に関する学生教育および神経内科若手医師の育成、よりすぐれた診療と研究を発展させていくことを目指します

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業績紹介

業績紹介

2016年

1) Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 2016, 628:207-212.
2) Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T,. Yamashita H, Ito H, Takahashi R, Urushitani M. CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. Sci Rep, 2016, 6: 19118;
3) Yanagihashi M, Kano O, Terashima T, Kawase Y, Hanashiro S, Sawada M, Ishikawa Y, Shiraga N, Ikeda K, Iwasaki Y. Late-onset spinal form xanthomatosis without brain lesion: a case report. BMC Neurol. 2016 Feb 9;16(1):21.
4) Maeda K, Kawai H, Sanada M, Terashima T, Ogawa N, Idehara R, Makiishi T, Yasuda H, Sato SI, Hoshi KI, Yahikozawa H, Nishi K, Itoh Y, Ogasawara K, Tomita K, Indo HP, Majima HJ. Clinical Phenotype and Segregation of Mitochondrial 3243A>G Mutation in 2 Pairs of Monozygotic Twins. JAMA Neurol. 2016 Jun 20.
5) Carandang A, Takamatsu N, Nodera H, Mori A, Mimura N, Okada N, Kinoshita H, Kuzuya A, Urushitani M, Takahashi R, Izumi Y, Kaji R. Velocity of intraneural blood flow is increased in inflammatory neuropathies: sonographic observation. J Neurol Neurosurg Psychiatr 2016, in press.
6) Kobatake Y, Sakai H, Tsukui T, Yamato O, Kohyama M, Sasaki J, Kato S, Urushitani M, Maeda S, Kamishina H. Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy. J Neurol Sci 2016, in press. DOI: http://dx.doi.org/10.1016/j.jns.2016.10.034
7) Kim H Oi J, Yamakawa I, Kawai H. String of pearls around the brainstem. A case of neurosarcoidosis. Neurology 2016, 87: 2602.

2015年

1) Kitamura A, Saito S, b, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalariad RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. J Cereb Blood Flow Metab, 2015 in press
2) Nakamae S, Kobatake Y, Suzuki R., Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, and Kamishina H. Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy. Neuroscience 2015 303, 229-40
3) Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T. A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice - Relevance to the pathogenesis of ALS. Hum Mol Genet. 2015. 15: 3427-3439.
4) Urabe H, Terashima T, Lin F, Kojima H, Chan L. Bone marrow-derived TNF-α causes diabetic neuropathy in mice. Diabetologia, 2015, 58: 402.
5) Urabe H, Terashima T, Kojima H, Chan L. Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy. Am J Physiol Endocrinol Metab. 2015

2014年

1) Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathologica Comm. 2014, 2, 172.
2) Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci 2014, 127, 5204–5217
3) Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K. Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine. Exp Biol Med 2014; 239: 489–501
4) Oono M, Okado-Matsumoto A, Shodai A, Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M. Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. J Neurochem 2014, 128 403-418
5) Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K. A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. Am J Hum Genet. 2014 Sep 4;95(3):294-300.
6) Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One,2014, 9: e92073.
7) Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H. Stem Cell Factor-Activated Bone Marrow Ameliorates Amyotrophic Lateral Sclerosis by Promoting Protective Microglial Migration. J. Neurosci. Res., 2014, 92: 856.
8) Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS letters., 2014, 588: 1080.

2013年

1) Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M. Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43). J Biol Chem 2013, 288, 21, 14886-14905.
2) Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat. Commun., 2013, 4:1526.

2012年

1) Shodai A,, Ido A, Fujiwara N, Ayaki T, Morimura T, Oono M, Uchida T, Takahashi R, Ito H, Urushitani M. Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLoS ONE 2012, 2012, 7, e52776
2) Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R. Motor Neuron-specific Disruption of Proteasomes, but not Autophagy, Replicates Amyotrophic Lateral Sclerosis. J Biol Chem, 2012, 287, 42984-4299 (YT and MU are co-first authors)
3) Terashima T, Kojima H, Chan L. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB J., 2012, 26 (1) : 295-308.
4) Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y. Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve. PLoS One., 2012, 7 (9): e44592.

2011年

1) Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto A, Takahashi R, Ito H. An autopsy case of SOD1-related ALS with TDP-43 positive inclusions. Neurology, 2011, 77, 1995-1997
2) Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R. Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model. PLoS ONE 2011, 6, e20427
3) Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I. In vivo detection of amyloid β deposition using (19)F magnetic resonance imaging with a (19)F-containing curcumin derivative in a mouse model of Alzheimer's disease. Neuroscience 2011,16, 184:120-127
4) Chan L, Terashima T, Urabe H, Lin F, Kojima H. Pathogenesis of diabetic neuropathy: bad to the bone. Ann. NY. Acad. Sci., 2011, 1240 (1) : 70-76.
5) Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H. Inactivation of TNF-α Ameliorates Diabetic Neuropathy in Mice. Am. J. Physiol. Endocrinol. Metab., 2011, 301 (5) : E844-852.

2010以前 (抜粋)

1) Kawai H, Nakajima A. Images in clinical medicine. Red puffy ears. N Engl J Med. 2010 Mar 11;362(10):928.
2) Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J. Clin. Invest., 2009, 119 (7) : 2100-2112.
3) Urushitani M, Ezzi SA, Matsuo A, Tooyama I, Julien JP. The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS. FASEB J 2008, 22: 2476-2487.
4) Urushitani M, Abou Ezzi S, Julien JP. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of ALS. Proc Natl Acad Sci U S A 2007, 104, 2495-2500
5) Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien JP. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 2006, 9:108-118
6) Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc. Natl. Acad. Sci. U.S.A., 2005, 102: 12525-12530.
7) Urushitani M, Shimohama S, Kihara T, Sawada H, Akaike A, Ibi M, Inoue R, Kitamura Y, Taniguchi T, Kimura J. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Ann Neurol 1998 44:796-807
8) Urushitani M, Udaka F, Kameyama M. Miller Fisher-Guillain-Barre overlap syndrome with enhancing lesions in the spinocerebellar tracts. J Neurol Neurosurg Psychiatry 1995, 58:241-3

著書

1) 玉木良高、漆谷 真. レドックスUPDATE「小胞体ストレスと神経変性疾患」. 淀井淳司・平家俊男監修 医歯薬出版株式会社2015, 213-219
2) 山下博史, 漆谷 真., 髙橋良輔. 脊髄の運動ニューロンとALS.分子脳科学. 三品昌美編. 化学同人2015年. 17-31
3) 漆谷 真.「嗜銀顆粒性認知症」認知症ハンドブック.中島健二、天野直二、下濱 俊、冨本秀和、三村 將 編.医学書院,東京,2013.750-755
4) 漆谷 真.「ALSにおけるワクチン・抗体療法の開発」アクチュアル脳・神経疾患の臨床『すべてがわかる筋萎縮性側索硬化症・運動ニューロン疾患』辻 省次、祖父江 元 編.中山書店,東京,2013, 275-281。
5) Urushitani M and Morimura T. Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis. Ed: Segawa K and Ijichi R, Nova Science Publishers, Inc. Hauppauge, 2012, 85-108.
6) 漆谷 真.「その他の原因、まれだが重要な疾患」認知症診療ハンドブック宇高不可思 編.医歯薬ジャーナル 2012 pp199-204
7) 漆谷 真,下濱 俊.運動ニューロン疾患.わかりやすい内科学.井村裕夫 編.文光堂,東京,1999,pp598-604
8) 下濱 俊,井村徹也,漆谷 真,大江田智子,景山 卓.神経系疾患の遺伝子学.臨床遺伝子学’ 98.最新医学社,大阪 1998, pp2475-2492
9) 漆谷 真,宇高不可思.肺性脳症.今日の神経疾患治療指針.亀山正邦,高倉公朋 編,医学書院,東京,1994, pp753-754
10) 宇高不可思,漆谷 真,亀山正邦.脳内出血の診断基準と鑑別診断.CT, MRI時代の脳卒中学.日本臨床,東京,1993, pp62-69